Home; Books; Search; Support. Gertrude Elion (1996) Antiviral Chemotherapy: Successes and Challenges Comment Few scientists who lived in the 20th century have helped to save so many lives as Gertrude Elion. Biographie. https://www.sciencehistory.org/.../george-hitchings-and-gertrude-elion in chemistry from New York University, and later received ten honorary doctorates. Elle travaille comme assistante de laboratoire puis comme professeur de lycée, avant de travailler, à partir de l'année 1944, avec George Hitchings pour la compagnie pharmaceutique Burroughs-Wellcome future GlaxoSmithKline. Un autre médicament, l'allopurinol, est efficace contre la goutte. ELION, GERTRUDE BELLE (b.New York, New York, 23 January 1918;. Quick Facts Name Gertrude B. Elion Occupation Chemist, Scientist Birth Date January 23, 1918 Death Date February 21, 1999 Education New York University, Hunter College Allopurinol and Other Inhibitors of Urate Synthesis GERTRUDE B. ELION A. Gertrude Elion (1918-1999) Née aux Etats-Unis, elle devient biochimiste et se voit attribuer le Prix Nobel de physiologie ou médecine en 1988. Gertrude Elion - Transplants and Antivirals - Gout As she investigated the implications and metabolism of her drugs, she was often able to discover new and effective medications. Hitchings received his bachelor’s She received her M.S. Gertrude Elion fait ses études au Hunter College et à l'Université de New York où elle obtient un master de science en 1941, mais ne pourra jamais obtenir de thèse. Introduction The ideal drug for the treatment of hyperuricemia would be one which reduces uric acid synthesis without interfering with important anabolic pathways or normal regu­ latory functions. Together with George H. Hitchings she not only discovered and developed the first drug to treat leukemia (6-mercaptopurine), the first immuno-suppressive agent (allopurinol) and the antiviral agent aciclovir. Avec Gertrude Elion ils ont développé de nouveaux agents actifs pour la lutte contre les infections des agents pathogènes dans les cellules hôtes, notamment dans le domaine des antirétroviraux : 6-mercaptopurine (Purinethol), le premier traitement pour la leucémie. In the 1940s, Gertrude Elion worked in the Hitchings Laboratory studying purines. Since . Gertrude Belle Elion was an outstanding biochemist and pharmacologist who received a Nobel Peace Prize in Physiology or Medicine in 1988 that was shared with Sir James W. Black and George H. Hitchings. Allopurinol was first synthesized and reported in 1956 by Roland K. Robins (1926-1992), in a search for antineoplastic agents. On the basis of such differences a series of drugs were developed that block nucleic acid synthesis in cancer cells and noxious organisms without damaging the normal human cells. Born: 1918 in New-York (USA) Death: 1999 in North Carolina (USA) Nobel Prize in Physiology or Medicine in 1988. Gertrude Belle Elion was an American biochemist and pharmacologist, and … Parmi les autres médicaments importants développés par George Hitchings et Gertrude Elion figurent la pyriméthamine, un antipaludéen, le triméthoprime, un médicament contreLire la suite. Fields: Medicine, Pharmacology, Biochemistry. https://www.chemistry.msu.edu/faculty-research/portraits/gertrude-belle-elion 1999-02-23 04:00:00 PDT Chapel Hill, N.C.-- Gertrude Belle Elion, a Nobel laureate who helped create drugs to combat such diseases as leukemia and herpes, has died at 81. Born in New York City, Elion attended Hunter College and graduated summa cum laude in 1937. Some medicines she helped discover and create are . Both were also influenced in their choice of career by personal grief: with Elion, it was the death of her beloved grandfather; for Hitchings, it was the passing of his father when he was 12 years. GERTRUDE B. ELION 1918–1999 A Biographical Memoir by MARY ELLEN AVERY Biographical Memoirs, VOLUME 78 PUBLISHED 2000 BY THE NATIONAL ACADEMY PRESS WASHINGTON, D.C. 17 I N THE SPRING OF 1933 Gertrude Elion graduated from high school and that summer she had to select a major subject before she could begin her freshman year at Hunter College. This posed a quandary for the … Gertrude Elion fait ses études au Hunter College et à l'Université de New York où elle obtient un master de science en 1941, mais ne pourra jamais obtenir de thèse. Gertrude Elion (New York, 1918ko urtarrilaren 23a - 1999ko otsailaren 21) biokimikari eta farmakologista estatubatuarra izan zen, 1988an Medikuntzako Nobel Saria jaso zuena.Hauek dira Elionen aurkikuntza nagusiak: 6-merkaptopurina, leuzemia tratatzeko Azatioprina, lehen gai immuno-supresiboa, organoen transplanteetan erabilia Alopurinol, hezueria tratatzeko. Gertrude Belle Elion, née le 23 janvier 1918 à New York aux États-Unis et morte le 21 février 1999 à Research Triangle en Caroline du Nord, est une pharmacologue et biochimiste américaine.Elle reçoit le Prix Nobel de physiologie ou médecine en 1988 pour ses découvertes dans l'élaboration de nouveaux médicaments.. Biographie. Gertrude Belle Elion (January 23, 1918, New York, USA – February 21, 1999, Chapel Hill, North Carolina, USA) was an American scientist, biochemist, and pharmacologist.. See the fact file below for more information on the Gertrude B. Elion or alternatively, you can download our 23-page Gertrude B. Elion worksheet pack to utilise within the classroom or home environment. Gertrude (“Trudy”) Belle Elion’s greatest legacy is the thousands of lives touched by the drugs she and her associates developed for the treatment of leukemia (6-Mercaptopurine or 6-MP), gout (allopurinol), rejection of transplanted organs (azathioprine), and herpes (acyclovir), among other disorders. Little was known at that time about the structure of DNA, aside from it likely including two purines and two pyrimidines. Such was the case with her novel medication for gout. "It's amazing how much you can accomplish when you don't care who gets the credit." George H. Hitchings and Gertrude B. Elion were children of the Great Depression, experiencing hardship and seeing family wealth dissolve during the economic collapse of the USA in the 1930s. Gertrude Elion fait ses études au Hunter College et à l'Université de New York où elle obtient un master de science en 1941, mais ne pourra jamais obtenir de thèse. Tout au long de sa carrière elle a développé de nouvelles molécules contre les infections des agents pathogènes dans le domaine des antirétroviraux, à savoir : - Le 6-mercatopurine, premier traitement contre la leucémie. Thiopurine Mechanism of Action and Metabolism George Herbert Hitchings, American pharmacologist who, along with Gertrude B. Elion and Sir James W. Black, received the Nobel Prize for Physiology or Medicine in 1988 for their development of drugs that became essential in the treatment of several major diseases. RHUMATOLOGIE. Gertrude "Trudy" Belle Elion (January 23, 1918 – February 21, 1999) was an American biochemist and pharmacologist , who shared the 1988 Nobel Prize in Physiology or Medicine with George H. Hitchings and Sir James Black for their use of innovative methods of rational drug design for the development of new drugs. Gertrude Belle Elion invented the leukemia-fighting drug 6-mercaptopurine and drugs that facilitated kidney transplants. Azathioprine (Imuran), le premier immunosuppresseur utilisé pour les transplantations d'organes. Naissance 23 janvier 1918 New York (États Unis) Décès 21 février 1999 Gertrude ELION 20th century. How-To Tutorials; Suggestions; Machine Translation Editions; Noahs Archive Project; About Us. Gertrude "Trudy" [2] Belle Elion (January 23, 1918 – February 21, 1999) was an American biochemist and pharmacologist, who shared the 1988 Nobel Prize in Physiology or Medicine with George H. Hitchings and Sir James Black for their use of innovative methods of rational drug design for the development of new drugs. Main achievements: Developed a multitude of new drugs, and the first immunosuppressive drug, azathioprine, used for organ transplants. Gertrude B. Elion's 213 research works with 13,492 citations and 2,268 reads, including: Ciba Foundation Symposium - Chemistry and Biology of Pteridines She was also given 45 patents and 23 honorary degrees. Working alone as well as with George H. Hitchings, Elion developed a multitude of new drugs, using innovative research methods that would later lead to the development of the AIDS drug AZT. Together with George H. Hitchings she not only discovered and developed the first drug to treat leukemia (6-mercaptopurine), the first immuno-suppressive agent (allopurinol) and the antiviral agent aciclovir. Gertrude Elion and George Hitchings, who have collaborated since 1945, demonstrated differences in nucleic acid metabolism between normal human cells, cancer cells, protozoa, bacteria and virus. Gertrude Elion (1996) Antiviral Chemotherapy: Successes and Challenges Comment Few scientists who lived in the 20th century have helped to save so many lives as Gertrude Elion. Gertrude Belle Elion (January 23, 1918 – February 21, 1999) was an American biochemist and pharmacologist, and a 1988 recipient of the Nobel Prize in Physiology or Medicine. d.Chapel Hill, North Carolina, 21 February 1999),pharmacology, antimetabolites, immunosuppressors, anticancer drugs, antiviral drugs. Gertrude Belle Elion: Pioneer of drug discovery, who was awarded a Nobel prize for developing drugs such as acyclovir and allopurinol.
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